Posted: March 30th, 2022

The NICE (National Institute for Health and Care Excellence) guidelines

Starting and maintenance regime for Mr. chavda

The NICE (National Institute for Health and Care Excellence) guidelines aim to improve TB spread ways. Antituberculosis is divided into intensive (initial) and a continuation phase. The initial stage seeks to eliminate the majority of organisms and prevent drug resistance rapidly, and the continuation phase is to eradicate dormant organisms. Direct observational therapy should be incorporated in case management to ensure treatment adherence.

Don't use plagiarized sources. Get Your Custom Essay on
The NICE (National Institute for Health and Care Excellence) guidelines
Just from $13/Page
Order Essay

Start the patient on Isoniazid (with pyridoxine), rifampicin, pyrazinamide and ethambutol for two months. Once TB is known to be fully susceptible, ethambutol is discontinued, then Isoniazid (with pyridoxine) and rifampicin for a further four months.

Patients taking pyrazinamide should undergo baseline and periodic serum uric acid assessments, and those taking ethambutol should undergo baseline and visual acuity and red-green colour perception testing


In case of isoniazid résistance, discontinue it and continue treatment with rifampin, pyrazinamide and ethambutol for six months. Therapy is extended if the patient has a cavitary disease and remains culture positive for two months after two months of treatment.

Isoniazid is used in combination with rifapentine. It inhibits the synthesis of mycolic acid resulting in disruption of bacterial cell wall .pyridoxine 25-50 mg once daily should be co-administered to prevent peripheral neuropathy.

Dosage: 5mg/kg PO/IM a day don’t exceed 300mg a day

Monitor for adverse effects, e.g. nausea and vomiting. Loss of appetite.

65kg (current weight for Mr Chavda) times 5mg =325mg, so administer 300 mg as per NICE guidelines.


Rifampin. Used in combination with at least one anti-TB drug for the treatment of active TB. It inhibits DNA dependent RNA polymerase activity in bacterial cells. In most sensitive cases patient undergoes six months of treatment but may last nine months if the patient’s sputum is positive after two months.

Adult dosage: 10mg/kg/day PO (peroral) or PO twice weekly DOT not to exceed 600mg/day

It May be given in conjunction with Isoniazid (INH) and pyrazinamide

65 times 10=650mg administer 600 mg for Mr. chavda


Pyrazinamide: this is a pyrazine analogue of nicotinamide that is either bacteriostatic or bactericidal against M tuberculosis. It is administered for initial two months 

Adult daily therapy: 15-30mg/kg/day not to exceed 2g/day

15 times 65=975g for Mr. Chavda daily

Twice weekly therapy 50mg/kg PO twice weekly not to exceed 2g/dose

It May be used in combination with Isoniazid and rifampinEthambutol: diffuses into mycobacterium cells, hindering cell metabolism by inhibiting the synthesis of 1 or more metabolites.

Adult dosage: daily administration

40 -55 kg: 800mg PO

56-75KG: 1.2g PO

  Above 75 kg 1.6 k.g

In case of combination therapy is used in Mr Chavda, the medical practitioners can utilise the FDCs (fixed-dose combination) schedule. FDCs are classified according to body weight, thus ensuring doses remain within therapeutic margins. For every drug, there is a therapeutic range that is effective and not toxic.

FDCs are improved formulations of a combination of two or more first-line anti TB drugs. These are rifampicin, isoniazid,pyrazinamide and ethambutol.

The schedule below shows dosage schedules for adults.



Get Professional Assignment Help Cheaply

Buy Custom Essay

Are you busy and do not have time to handle your assignment? Are you scared that your paper will not make the grade? Do you have responsibilities that may hinder you from turning in your assignment on time? Are you tired and can barely handle your assignment? Are your grades inconsistent?

Whichever your reason is, it is valid! You can get professional academic help from our service at affordable rates. We have a team of professional academic writers who can handle all your assignments.

Why Choose Our Academic Writing Service?

  • Plagiarism free papers
  • Timely delivery
  • Any deadline
  • Skilled, Experienced Native English Writers
  • Subject-relevant academic writer
  • Adherence to paper instructions
  • Ability to tackle bulk assignments
  • Reasonable prices
  • 24/7 Customer Support
  • Get superb grades consistently

Online Academic Help With Different Subjects


Students barely have time to read. We got you! Have your literature essay or book review written without having the hassle of reading the book. You can get your literature paper custom-written for you by our literature specialists.


Do you struggle with finance? No need to torture yourself if finance is not your cup of tea. You can order your finance paper from our academic writing service and get 100% original work from competent finance experts.

Computer science

Computer science is a tough subject. Fortunately, our computer science experts are up to the match. No need to stress and have sleepless nights. Our academic writers will tackle all your computer science assignments and deliver them on time. Let us handle all your python, java, ruby, JavaScript, php , C+ assignments!


While psychology may be an interesting subject, you may lack sufficient time to handle your assignments. Don’t despair; by using our academic writing service, you can be assured of perfect grades. Moreover, your grades will be consistent.


Engineering is quite a demanding subject. Students face a lot of pressure and barely have enough time to do what they love to do. Our academic writing service got you covered! Our engineering specialists follow the paper instructions and ensure timely delivery of the paper.


In the nursing course, you may have difficulties with literature reviews, annotated bibliographies, critical essays, and other assignments. Our nursing assignment writers will offer you professional nursing paper help at low prices.


Truth be told, sociology papers can be quite exhausting. Our academic writing service relieves you of fatigue, pressure, and stress. You can relax and have peace of mind as our academic writers handle your sociology assignment.


We take pride in having some of the best business writers in the industry. Our business writers have a lot of experience in the field. They are reliable, and you can be assured of a high-grade paper. They are able to handle business papers of any subject, length, deadline, and difficulty!


We boast of having some of the most experienced statistics experts in the industry. Our statistics experts have diverse skills, expertise, and knowledge to handle any kind of assignment. They have access to all kinds of software to get your assignment done.


Writing a law essay may prove to be an insurmountable obstacle, especially when you need to know the peculiarities of the legislative framework. Take advantage of our top-notch law specialists and get superb grades and 100% satisfaction.

What discipline/subjects do you deal in?

We have highlighted some of the most popular subjects we handle above. Those are just a tip of the iceberg. We deal in all academic disciplines since our writers are as diverse. They have been drawn from across all disciplines, and orders are assigned to those writers believed to be the best in the field. In a nutshell, there is no task we cannot handle; all you need to do is place your order with us. As long as your instructions are clear, just trust we shall deliver irrespective of the discipline.

Are your writers competent enough to handle my paper?

Our essay writers are graduates with bachelor's, masters, Ph.D., and doctorate degrees in various subjects. The minimum requirement to be an essay writer with our essay writing service is to have a college degree. All our academic writers have a minimum of two years of academic writing. We have a stringent recruitment process to ensure that we get only the most competent essay writers in the industry. We also ensure that the writers are handsomely compensated for their value. The majority of our writers are native English speakers. As such, the fluency of language and grammar is impeccable.

What if I don’t like the paper?

There is a very low likelihood that you won’t like the paper.

Reasons being:

  • When assigning your order, we match the paper’s discipline with the writer’s field/specialization. Since all our writers are graduates, we match the paper’s subject with the field the writer studied. For instance, if it’s a nursing paper, only a nursing graduate and writer will handle it. Furthermore, all our writers have academic writing experience and top-notch research skills.
  • We have a quality assurance that reviews the paper before it gets to you. As such, we ensure that you get a paper that meets the required standard and will most definitely make the grade.

In the event that you don’t like your paper:

  • The writer will revise the paper up to your pleasing. You have unlimited revisions. You simply need to highlight what specifically you don’t like about the paper, and the writer will make the amendments. The paper will be revised until you are satisfied. Revisions are free of charge
  • We will have a different writer write the paper from scratch.
  • Last resort, if the above does not work, we will refund your money.

Will the professor find out I didn’t write the paper myself?

Not at all. All papers are written from scratch. There is no way your tutor or instructor will realize that you did not write the paper yourself. In fact, we recommend using our assignment help services for consistent results.

What if the paper is plagiarized?

We check all papers for plagiarism before we submit them. We use powerful plagiarism checking software such as SafeAssign, LopesWrite, and Turnitin. We also upload the plagiarism report so that you can review it. We understand that plagiarism is academic suicide. We would not take the risk of submitting plagiarized work and jeopardize your academic journey. Furthermore, we do not sell or use prewritten papers, and each paper is written from scratch.

When will I get my paper?

You determine when you get the paper by setting the deadline when placing the order. All papers are delivered within the deadline. We are well aware that we operate in a time-sensitive industry. As such, we have laid out strategies to ensure that the client receives the paper on time and they never miss the deadline. We understand that papers that are submitted late have some points deducted. We do not want you to miss any points due to late submission. We work on beating deadlines by huge margins in order to ensure that you have ample time to review the paper before you submit it.

Will anyone find out that I used your services?

We have a privacy and confidentiality policy that guides our work. We NEVER share any customer information with third parties. Noone will ever know that you used our assignment help services. It’s only between you and us. We are bound by our policies to protect the customer’s identity and information. All your information, such as your names, phone number, email, order information, and so on, are protected. We have robust security systems that ensure that your data is protected. Hacking our systems is close to impossible, and it has never happened.

How our Assignment  Help Service Works

1.      Place an order

You fill all the paper instructions in the order form. Make sure you include all the helpful materials so that our academic writers can deliver the perfect paper. It will also help to eliminate unnecessary revisions.

2.      Pay for the order

Proceed to pay for the paper so that it can be assigned to one of our expert academic writers. The paper subject is matched with the writer’s area of specialization.

3.      Track the progress

You communicate with the writer and know about the progress of the paper. The client can ask the writer for drafts of the paper. The client can upload extra material and include additional instructions from the lecturer. Receive a paper.

4.      Download the paper

The paper is sent to your email and uploaded to your personal account. You also get a plagiarism report attached to your paper.

smile and order essaysmile and order essay PLACE THIS ORDER OR A SIMILAR ORDER WITH US TODAY AND GET A PERFECT SCORE!!!

order custom essay paper

Expert paper writers are just a few clicks away

Place an order in 3 easy steps. Takes less than 5 mins.

Calculate the price of your order

You will get a personal manager and a discount.
We'll send you the first draft for approval by at
Total price:
Open chat
Need assignment help? You can contact our live agent via WhatsApp using +1 718 717 2861

Feel free to ask questions, clarifications, or discounts available when placing an order.